Determinations of the concentration of ascorbic acid in whole blood (1, 2, 3, 4, 5, 6, 7, 8) and in plasma or serum (9, 10, 11, 12, 13, 14, 15, 16, 17, 18) as well are believed to indicate the degree of saturation of the organism. No strict correlation, however, has been established between the ascorbic acid content of whole blood and of plasma, although the concentration in cells is consistently higher than in plasma under ordinary conditions (5). The present investigation deals with the distribution of ascorbic acid in blood before and during absorption of test doses of ascorbic acid, the relationship of its concentration in whole blood and in serum to the amounts eliminated in urine. The distribution between cells and serum of ascorbic acid added to blood in vitro has also been observed.
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